For every research, choosing the right peptide synthesizer can be a challenge. When you want to do peptide synthesis, you should consider a synthesizer for it.
Synthesizers have the power to perform a synthesis of multiple compounds easily and effectively. But only purification is carried out on a single compound.
But before choosing one peptide synthesizer, there are several things that have to be brought under your consideration. These are:
Question of parallel synthesis and performance
In research, different phases and applications need different amounts of peptides. A drug recovery program for peptides involves the detection of hundreds and thousands of peptides.
This helps to optimize the SAR (Structure Activity Relations) and libraries focused to detect a single candidate, which is quite advanced.
But to be successful, it is mandatory to go for synths that have reaction vessels. It’s mainly because it can provide a level of parallel synthesis that you might need to match your application.
The synthesis scale
when for each peptide synthesisresearchers might need a different amount of peptide.
For example, the amount of peptide materials will increase dramatically as peptide therapies undergo early-stage detection, leading to preclinical development and optimization.
Here, using the right peptide synthesizer will help meet your needs and also give you flexibility throughout the process.
Find a partner to meet your peptide synthesis needs
For most production facilities and laboratories, a peptide synthesizer is extremely important. It will provide you with years of error-free operations and will also improve the productivity of your team.
On top of that, the synthesizer can provide much greater flexibility to meet both anticipated and current needs. Therefore, when you are on a budget or need to make some changes to the pool, you should opt for a system that comes with additional capabilities or features.
You should look for an implementation partner who can offer you the support you need to ensure you reach your goals on time.
Special Chemical Need
Researchers are synthesizing common linear peptides or can create cyclic peptoids, peptides, and other peptidomimetics. There are some who work with Oligos, PMOs and PNAs.
For the synthesis of cyclic peptides, you should use the reaction steps and the protected amino acid derivatives for orthogonal cyclization and deprotection. The synthesis of “peptoids” and oligomimetics, PNAs and oligos may require unique reagents and monomers.
To make these molecules, experts will need an instrument that provides a high level of flexibility in terms of bottle positions and protocol. This is why many of the instruments use more than 40 amino acids instead of being restricted to using only 20 positions for all natural amino acids.
Most of the reagents and monomers used for all of these specialty chemicals can be quite expensive. So many synths act as a great addition to make sure nothing goes to waste.
The information in this post clearly tells you about the various things to consider when planning to use a synthesizer. Be sure to go over the points correctly to have a good understanding.