Connect with us

Health Care

Ipsen bets on Exicure technology as a better way to deliver neuropharmaceuticals deep into the brain

Published

on

Ipsen bets on Exicure technology as a better way to deliver neuropharmaceuticals deep into the brain

One of the challenges in developing drugs that address neurological disorders is getting enough therapy in the brain. Exicure has proprietary technology that improves a therapy’s ability to penetrate cells and last longer compared to currently available drug types and Ipsen sees enough potential to start a camaraderie in drugs for two rare neurological disorders without therapeutic options.

Under the terms of the deal announced Monday, Paris-based Ipsen will pay Exicure $ 20 million in advance to start the alliance. In return, Ipsen gets exclusive options to license the Huntington’s disease and Angelman syndrome therapies that Exicure is developing with its proprietary technology.

Exicure will fund drug discovery and development work. If Ipsen exercises its option in one or more of the programs, it will assume responsibility for further drug development and commercialization if approved. The agreement also requires Ipsen to pay its partner up to $ 1 billion in option exercise fees and milestone payments if it exercises the option in both programs. Exicure will receive royalties on the sales of the drugs if they hit the market.

Some of the drugs for neurological disorders are oligonucleotides, synthetic nucleic acid structures that can modulate gene expression. But the use of this type of drug is limited by the inability to deliver a sufficient amount of the therapy to the organs and tissues.

Chicago-based Exicure is developing a technology based on what it calls spherical nucleic acids (SNAs). These drugs are nanoscale constructs of densely packed synthetic nucleic acid sequences that are arranged in a three-dimensional structure that, according to the company, improves a therapy’s cellular penetration, distribution throughout the body, and its persistence in organs. Specifically, this structure enters cells through class A scavenger receptors, which are commonly found on the surface of cells throughout the body, the company said in regulatory documents. The company added that this mechanism of entry into cells is different from that used by other nucleic acid therapies that generally bind to receptors found only on liver cells. In a prepared statement, Exicure CEO David Giljohann said that the treatment of both Huntington and Angelman requires penetration of a drug deep into the brain.

“We believe that our platform technology with its deep penetration and persistent medicinal effect will allow Exicure and Ipsen to overcome the challenges of first-generation oligonucleotides and bring new drugs to patients who need them,” he said.

Exicure’s technology has spawned programs in cancer, dermatology, and neuroscience. The most advanced cancer program is cavrotolimod, which is in phase 1b / 2 testing for Merkel cell carcinoma and cutaneous squamous cell carcinoma. In neuroscience, the most advanced Exicure program is XCUR-FXN, a preclinical drug for Friedreich’s ataxia that the company hopes to incorporate into human trials next year. A dermatology program for hair loss disorders is in preclinical development in collaboration with AbbVie.

For Ipsen, the deal with Exicure is the third the company has completed in recent weeks. On July 15, the company agreed pay IRLAB $ 28 million in advance for the global rights to mesdopetam, a drug in intermediate stage of clinical development for patients with Parkinson’s disease. The milestone payments could add another $ 335 million to the deal. In the second deal, Ipsen agreed last week pay BAKX Therapeutics $ 14.5 million in advance to obtain the rights to a preclinical small molecule under development for potential applications in the treatment of leukemia, lymphoma and solid tumors. The milestone payments could bring an additional $ 837.5 million to BAKX.

Image: Jolygon via Getty Images

Advertisement
Advertisement

Lifestyle

LifeStyle2 days ago

Tips to Boost Your Energy and Ensure Life Longevity with NMN Supplements

Australia’s median age limit increased by two years recently. Higher NAD+ can improve your metabolism rates and prolong natural aging....

LifeStyle1 month ago

5 Tips on Writing APA Research Paper

When students reach college education, they understand that it won’t all be flowers and sunshine. There are different courses with...

Support group for businesses to overcome challenges Support group for businesses to overcome challenges
LifeStyle2 months ago

Support group for businesses to overcome challenges

All-day brunch and soup kitchen Cafe Coco suffered as walk-ins dwindled significantly. It’s a tourist-dependent cafe that’s nestled in the...

S’pore startup Shiok Meats acquires clean red meat company Gaia Foods S’pore startup Shiok Meats acquires clean red meat company Gaia Foods
LifeStyle2 months ago

S’pore startup Shiok Meats acquires clean red meat company Gaia Foods

According to Technology in Asia, Shiok Meats has acquired a stake of more than 90% in Gaia Foods for an...

Marianna Hewitt’s home proves that neutral decor can be full of personality Marianna Hewitt’s home proves that neutral decor can be full of personality
LifeStyle2 months ago

Marianna Hewitt’s home proves that neutral decor can be full of personality

If anyone understands the importance of maintaining your brand, it is Marianna Hewitt. The trusted influencer and founder of the...

The 16 best stuffed pepper recipes for every occasion The 16 best stuffed pepper recipes for every occasion
LifeStyle2 months ago

The 16 best stuffed pepper recipes for every occasion

Something you may not know about me is that I absolutely adore a pepper. Raw, cooked, marinated, bathed: each and...

Top 10 Bedroom Plants That Work As Air Purifying Plants Top 10 Bedroom Plants That Work As Air Purifying Plants
LifeStyle2 months ago

Top 10 Bedroom Plants That Work As Air Purifying Plants

Setting a specific tone in a bedroom can happen in many ways. A beautiful candle, plush rugs, soft bedding, soothing...

Breakdown of MDEC’s DIF5 Strategy to Achieve MyDIGITAL Goals Breakdown of MDEC’s DIF5 Strategy to Achieve MyDIGITAL Goals
LifeStyle2 months ago

Breakdown of MDEC’s DIF5 Strategy to Achieve MyDIGITAL Goals

On July 19, 2021, MDEC announced a five-year plan aimed at enhancing Malaysia’s digital economy, Future 5 Digital Investments (DIF5)....

What you should know about personal loans in Malaysia What you should know about personal loans in Malaysia
LifeStyle2 months ago

What you should know about personal loans in Malaysia

[This is a sponsored article with Citibank.] Let’s face it, personal loans don’t I always have the best representative. Seeing...

A new way for Malaysians to support selected local brands A new way for Malaysians to support selected local brands
LifeStyle2 months ago

A new way for Malaysians to support selected local brands

As a media publication that amplifies the voices of local brands, Vulcan Post has looked at the variety of challenges...

Advertisement

Sport

Sports1 month ago

5 Tips for Setting Up Your PC for Online Gaming

Due to advances in technology, online gamers can enjoy a gaming experience that was unthinkable even a decade ago. High-resolution...

Sports2 months ago

How to Succeed in Poker Tournaments

Perhaps your first big poker tournament is coming up, or you’ve been gathering skills ready to enter – no matter...

Sports2 months ago

Is The Olympics Still Relevant?

As the Tokyo Olympics has come to a close, competitors must move on from the excitement of experiencing an Olympic...

Fernández reflects on the game against Dart: ‘Honestly, I can’t think of anything positive’ Fernández reflects on the game against Dart: ‘Honestly, I can’t think of anything positive’
Sports2 months ago

Fernández reflects on the game against Dart: ‘Honestly, I can’t think of anything positive’

var adServerUrl = “”; var $ el = $ (“# video_container-985707”); var permalink = $ el.closest (‘. snet-single-article’). data (‘permalink’);...

Tammy Abraham to Roma – Mourinho is the perfect coach for the striker Tammy Abraham to Roma – Mourinho is the perfect coach for the striker
Sports2 months ago

Tammy Abraham to Roma – Mourinho is the perfect coach for the striker

It seems that not too long ago, a young English Target Man was a troubling prospect for most Premier League...

Explanation: Why Barcelona had to let Messi go Explanation: Why Barcelona had to let Messi go
Sports2 months ago

Explanation: Why Barcelona had to let Messi go

Barcelona’s Argentine forward Lionel Messi cries during a press conference at Barcelona’s Camp Nou stadium on August 8, 2021. –...

Are Arsenal and Spurs left out of the top 6 in dispute as the 2021/22 season approaches? Are Arsenal and Spurs left out of the top 6 in dispute as the 2021/22 season approaches?
Sports2 months ago

Are Arsenal and Spurs left out of the top 6 in dispute as the 2021/22 season approaches?

Manchester United, Manchester City, Liverpool, Chelsea, Spurs and Arsenal are the teams that are widely regarded as the top 6...

What should team Canada’s men’s hockey roster look like? What should team Canada’s men’s hockey roster look like?
Sports2 months ago

What should team Canada’s men’s hockey roster look like?

We have sent an email with instructions to create a new password. Your current password has not been changed. We...

Haaland, but staying in Dotmund, can BVB get the title on 21/22? Haaland, but staying in Dotmund, can BVB get the title on 21/22?
Sports2 months ago

Haaland, but staying in Dotmund, can BVB get the title on 21/22?

There are almost twenty days left in the transfer window. The window is in full swing as deals that would...

Knicks agree to deal with Dwayne Bacon: reports Knicks agree to deal with Dwayne Bacon: reports
Sports2 months ago

Knicks agree to deal with Dwayne Bacon: reports

Dwayne Bacon # 8 of the Orlando Magic shoots as John Collins # 20 of the Atlanta Hawks defends during...

Advertisement

Entertainment

Venice adds Doc ‘Ennio’;  Netflix Confirms Sanjay Leela Bhansali Series – News Block Venice adds Doc ‘Ennio’;  Netflix Confirms Sanjay Leela Bhansali Series – News Block
Entertainment2 months ago

Venice adds Doc ‘Ennio’; Netflix Confirms Sanjay Leela Bhansali Series – News Block

Venice adds Giuseppe Tornatore’s Ennio Morricone film The Venice Film Festival incorporates the Out of Competition screening of Ennio Morricone’s...

The Jeffrey Epstein Victims Fund has finished paying $ 121 million The Jeffrey Epstein Victims Fund has finished paying $ 121 million
Entertainment2 months ago

The Jeffrey Epstein Victims Fund has finished paying $ 121 million

After awarding more than $ 121 million to about 150 applicants, a compensation program for survivors of Jeffrey Epstein’s sexual...

Matt Roloff and Karyn Chandler move in together, discuss marriage Matt Roloff and Karyn Chandler move in together, discuss marriage
Entertainment2 months ago

Matt Roloff and Karyn Chandler move in together, discuss marriage

Small people, big world star Matt Roloff and his girlfriend, Karyn Chandlerhave revealed their big summer plans in a new...

Mike Shouhed wants Reza Farahan to apologize for being a ‘traitor’ Mike Shouhed wants Reza Farahan to apologize for being a ‘traitor’
Entertainment2 months ago

Mike Shouhed wants Reza Farahan to apologize for being a ‘traitor’

Shouhed says his Shahs of Sunset co-star “cuts deep and says things that are hard to forgive.” While a sexting...

Joey Lawrence and Samantha Cope are engaged Joey Lawrence and Samantha Cope are engaged
Entertainment2 months ago

Joey Lawrence and Samantha Cope are engaged

He put a ring on it! Joey lawrence is engaged to the actress Samantha cope one year after filing for...

Christine Applegate was diagnosed with multiple sclerosis Christine Applegate was diagnosed with multiple sclerosis
Entertainment2 months ago

Christine Applegate was diagnosed with multiple sclerosis

August 10, 2021 Christine Applegate was diagnosed with multiple sclerosis (MS). Christina Applegate The 49-year-old actress took to Twitter on...

UK advertisers form tapestry with clients Coel, Fassbender, Foy – News Block UK advertisers form tapestry with clients Coel, Fassbender, Foy – News Block
Entertainment2 months ago

UK advertisers form tapestry with clients Coel, Fassbender, Foy – News Block

EXCLUSIVE: UK advertisers Donna Mills and Emma Jackson, longtime representatives of London-based Premier Communications, have launched the new advertising agency...

Christina Applegate: actress reveals multiple sclerosis diagnosis Christina Applegate: actress reveals multiple sclerosis diagnosis
Entertainment2 months ago

Christina Applegate: actress reveals multiple sclerosis diagnosis

prime time Emmy-winning actor Christina applegate has revealed a multiple sclerosis condition through a Twitter post late on Monday night....

Prince Harry and Meghan Markle wanted to move to New Zealand in 2018 Prince Harry and Meghan Markle wanted to move to New Zealand in 2018
Entertainment2 months ago

Prince Harry and Meghan Markle wanted to move to New Zealand in 2018

Prince harry and Meghan Markle according to Queen Elizabeth IIRepresentative to New Zealand, Governor General Patsy Reddy… She said Associated...

Alarming new UN climate report says humanity has really screwed itself up Alarming new UN climate report says humanity has really screwed itself up
Entertainment2 months ago

Alarming new UN climate report says humanity has really screwed itself up

The last evaluation of climate science is a “code red for humanity,” the United Nations chief said on Monday, while...

Advertisement

Tech

Tech4 days ago

How Serious is Plagiarism in College?

Studying in college often demands writing essays and course papers. You may study technical subjects and do not have many...

Tech5 days ago

Three Possible Ways of How You Can Transfer Contacts from Outlook to iPhone

MS Outlook plays an important role in putting daily life in order, especially with regard to email management. If you...

Tech6 days ago

Importance of Email Validation

According to recent stats, 30% of users change their email every year. Therefore, if your mailing list is more than...

Tech6 days ago

Before Doing Virtual Staging, Here’s What You Should Know

The majority of people today go online to look for homes. When a potential buyer spots a house online that...

Tech2 weeks ago

What Technologies are Online Casinos Using?

Online casinos have become an ideal choice for a lot of players, especially because they let players take their games...

Tech4 weeks ago

Grow Your Brand With These 5 Social Media Tips

Whether you’re operating a new business or working to grow your brand, social media is an excellent place to start....

Tech1 month ago

Is Mining Ethereum Still Profitable in 2021?

Globally, there have been lots of innovations and modernization in different aspects of life. This fact has contributed to the...

Tech1 month ago

Popularity Of the Blockchain Technology: How Familiar Are You with It?

Cryptocurrencies are a form of digital currency that stands out because it is decentralized. Cryptocurrency also stands out because it...

Tech2 months ago

5 Most Effective Tips For Speeding Up A Mac

Are you facing speed issues with your MacBook? Do you feel it needs to be repaired or replaced with a...

The frozen cave lion still has whiskers and hair despite being 28,000 years old The frozen cave lion still has whiskers and hair despite being 28,000 years old
Tech2 months ago

The frozen cave lion still has whiskers and hair despite being 28,000 years old

They are not lions. A nearly 28,000-year-old female cave lion cub, nicknamed Sparta, may be the best-preserved Ice Age animal...

Advertisement
Advertisement